<small id="f2xv5"></small>

  •
    • <cite id="f2xv5"></cite>

        



        
  
        
  	
        
    	
        德思特生物專注于中藥（植物藥）物質基礎研究以及天然化合物、中藥化學對照品實物生產供應
        
        
    
        
  
        
  
  
        
	
        
    
    

        天然藥物活性單體及中藥對照品專業生產供應商

        
    
        聯系方式
        028-85003950
        
    
        
   
        
   
   
        
   	  
    
        

        



        
	
        
		
	
        

        




        
	
        
   	  
    


        
        
        
        	
        
        		
                
                
                
                
        
                	
        聯系方式
        
                	
        
                    	
        服務熱線：
        028-8500-3950
        公司傳真：028-85589956
        公司郵箱：sales@tcmlmt.com
        公司網址：chuaihan.com
        公司地址：四川省成都市溫江區?？坡肺鞫?28號5棟

                            
        
                
        
                
        	
        
            
        
            
        		
        
                	  
        
                        
        發表文獻展示
        
                        當前位置:首頁關于德思特 > 發表文獻展示 > 
                      
        
                      
        
                   		  
        
                   		  		
        Chemosphere - 24 December 2019 異甘草素 CAS 961-29-5
        
                   		  		
        時間：2020-09-03   瀏覽次數：  分享到：
        
                   		  			
        
                   		  		
        
                   		  		
        
                   		  			Isoliquiritigenin triggers developmental toxicity and oxidative stress–mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway
        
期刊名：Chemosphere
        
文獻編號：https://doi.org/10.1016/j.chemosphere.2019.125727
        
文獻地址：https://www.sciencedirect.com/science/article/abs/pii/S0045653519329686?via%3Dihub
        
發表日期：May 2020
        

        
Abstract
        
Isoliquiritigenin (ISL) is an emerging natural flavonoid found in the roots of licorice, exhibits antioxidant, anti-cancer, anti-inflammatory, anti-allergic, cardioprotective, hepatoprotective and neuroprotective properties. However, the effect of ISL in embryonic development is yet to be elucidated, and the mechanisms underlying its target-organ toxicity and harmful side effects are still unclear. In the present study, we employed zebrafish embryos to study the developmental toxicity effect of ISL and its underlying mechanisms. Zebrafish embryos upon treatment with either vehicle control (0.1% DMSO) or ISL solutions for 4–96 h post fertilization (hpf) showed that ISL exposure instigated severe developmental toxicity in heart, liver, and nervous system. Mortality and morphological abnormalities were also observed. High concentrations of ISL exposure resulted in abnormal phenotypes and embryonic malformations including pericardial edema, swim bladder defects, yolk retention, curved body shape and shortening of body length. Moreover, ISL exposure led to significant loss of dopaminergic neurons accompanied by reduced locomotor behaviour. Apoptotic cells were predominantly located in the heart area of 96 hpf embryo. Additionally, ISL significantly increased the levels of reactive oxygen species, lipid peroxidation content and decreased antioxidant enzyme activities. The expressions pattern of apoptosis-related genes Bad, Cyto c, Caspase-9, Caspase-3 and Bax/Bcl-2 indicated that the oxidative stress–induced apoptosis triggered by ISL suggest involvement of Nrf2-HO1/JNK-ERK/mitochondrion pathways. In conclusion, here we provide first evidence that demonstrate ISL-induced dose-dependent developmental toxicity in zebrafish embryos. Furthermore, gene expression patterns in the embryos correlate the above and reveal potential genetic mechanisms of developmental toxicity.
        

        
Isoliquiritigenin (ISL) is was purchased from Chengdu DeSiTe  Biological Technology Co., Ltd. (Sichuan, China).
        

        

        
                   		  		
        
                   		  		
                   		  
        
                      	  
                      
        
                
        
                
                
        
                	
        
                        
        熱門新聞
        
                    
        
                    
        
                        					                                                  
        
                            
                            
        
                                
        Afrormosine CAS:550-79-8 中藥對照品標準品
        
                                
        產品編碼：DA0040產品名稱：Afrormosine英文名:AfrormosineCAS登錄...
        
                                查看更多
                            
        
                        
        
                        
          
                                                   
        
                                                                    
        
                    
                    
                
        
                
        	
        
        
        
        
    
        

        










        
	
        
	
        
        
        
        
    
        

        


        
	
        
		
    
        
    
        
		
        
		 
        德思特
        
		 
        
		 	版權所有：成都德思特生物技術有限公司 Copyright © 2016   蜀ICP備16023840號-2
        
公司地址：四川省成都市溫江區海科路西段128號5棟
        
公司電話：028-85003950
        

        
		 
        
		 
        掃一掃關注德思特
           掃碼關注公眾號
         
        
		
        		
	
        	

        
 
     
     
     
     





四虎国产永久免费久久_狠狠躁夜夜躁人人爽天天30人_成人动漫在线免费观看_久久婷婷激情综合色综合俺也去

        <small id="f2xv5"></small>
      2. 

        

        4. <cite id="f2xv5"></cite>